In vitro transformation of hamster embryo cells with tryptophan pyrolysis products.
نویسندگان
چکیده
منابع مشابه
Enhanced virus transformation of hamster embryo cells in vitro.
Since transformation of hamster cells in vitro by simian virus 40 (SV40) is a rare event in a homogeneously infected cell population, physiochemical studies of the events of virus transformation are difficult. Similarly, other deoxyribonucleic acid-containing oncogenic viruses produce transformed-cell foci in vitro with low efficiency. Sublethal doses of X-ray irradiation, as well as preincubat...
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Cell culture provides a potentially useful system for studying carcinogenesis, but available systems of transformation in vitro have limitations. Permanent, non-tumorigenic mouse-embryo cell lines have been widely used, but were shown to form tumours when grown on solid supports and implanted into mice (Boone, 1976), and so may represent a pre-neoplastic rather than a normal state. The use of e...
متن کاملLymphotropic papovavirus transformation of hamster embryo cells.
Hamster embryo cells were transformed by African green monkey lymphotropic papovavirus (LPV). The transformed cells contained intranuclear T-antigens demonstrable by fluorescent antibody staining with hamster anti-LPV serum. Analysis of uncloned and cloned lines of transformed cells for LPV sequences revealed that the viral DNA was present as free nonintegrated and integrated genomes; there wer...
متن کاملSpontaneous neoplastic transformation in vitro of mouse whole embryo cells and newborn hamster lung cells.
Three cell lines, spontaneously transformed in vitro, MWE-l and MWE-2 originating from C3Hf/Bi mouse whole embryos and NHLu-l originating from newborn syrian hamster lungs were obtained. These transformed cell lines were characterized by short generation time, marked aneuploidy in chromosome numbers and tumor induction in vivo. Histological appearance of the tumors induced by MWE-l was fibrosar...
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The RNA catabolice 7-methylguanine has been shown to inhibit queuine modification of tRNA in Chinese hamster embryo cells under conditions leading to in vitro transformation. Phorbol ester tumor pro moters also induce queuine hypomodification of tRNA in normal human cells, and this effect was reported to be correlated directly to the appear ance of an altered (transformed) cell phenotype. Based...
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ژورنال
عنوان ژورنال: Proceedings of the Japan Academy, Series B
سال: 1977
ISSN: 0386-2208,1349-2896
DOI: 10.2183/pjab.53.126